Idiopathic thrombocytopenic purpura (ITP) is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. 19 Jan Read our article and learn more on MedlinePlus: Immune thrombocytopenic purpura (ITP). 23 Feb Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.

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See Treatment and Medication for more detail. The diagnosis of ITP is a process of exclusion. In chronic refractory cases, where immune pathogenesis has been confirmed, [15] the off-label use of the vinca alkaloid [16] [17] [18] and chemotherapy agent vincristine may be attempted. Not to be confused with autoimmune thrombotic thrombocytopenic purpura.

In chronic ITP adultsthe female-to-male ratio is 2. Petechia of the lower leg in a person with platelets of 3 due to ITP. Acute renal failure after intravenous anti-D immune globulin in an adult with immune thrombocytopenic purpura.

The resulting shortened life span of platelets in the circulation, together with incomplete compensation by increased platelet production by bone marrow megakaryocytes, results in a decreased platelet count.


Acute primary ITP is more common in children years of age, with similar incidence between males and females, while the chronic form is usually encountered in adults with median age of years. Cost and mortality associated with hospitalizations in patients with immune thrombocytopenic purpura. After several weeks of prednisone therapy, the dose is gradually reduced. Vascular complications after splenectomy for hematologic disorders.


See Clinical Presentation for more detail. In children, the disease affects boys and girls equally. Provan D, Newland AC.

Immune Thrombocytopenic Purpura (ITP): Practice Essentials, Background, Pathophysiology

What would you like to print? Support Center Support Center. The most likely causes in these persons are myelodysplastic syndromesacute leukemia, and marrow infiltration myelophthisis. N Engl J Med. A French study reported an incidence of ITP of 2.

Zarrabi MH, Rosner F. General care includes explaining ITP to the patient and advising him or her to watch for bruising, petechiae, or other signs of recurrence. Eradication of Helicobacter pylori increases platelet count in patients with idiopathic thrombocytopenic purpura in Japan.

Freckles lentigo melasma nevus melanoma. Nevertheless, in the case of an ITP patient already scheduled for surgery who has a dangerously low platelet count and has experienced a poor response to other treatments, IVIg can rapidly increase platelet counts, and can also help reduce the risk of major bleeding by transiently increasing platelet counts.

Immune thrombocytopenic purpura (ITP)

The incidence of ITP is new cases per million per year, with children accounting for half of that amount and the median age of adults at the diagnosis is There is purpur use of immunosuppressants such as mycophenolate mofetil and azathioprine because of their effectiveness.

Once the platelet count has improved, the dose trombositopeniz steroid is gradually reduced while the possibility of relapse is monitored. Hannover, Helwig, Allergic contact dermatitis Mantoux test.

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From Wikipedia, the free encyclopedia. Pregnant women require special consideration for delivery, as follows [ 18 ]:. The Netherlands Journal of Medicine. With epidermal involvement Trombositoppenia contact dermatitis atopic dermatitis seborrheic dermatitis stasis dermatitis lichen simplex chronicus Darier’s purpuga glucagonoma syndrome langerhans cell histiocytosis lichen sclerosus pemphigus foliaceus Wiskott—Aldrich syndrome Zinc deficiency.

View our new CAP’18 videos by clicking here. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura.

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Recurrent idiopathic thrombocytopenic purpura in childhood. The pros and cons of drug therapy for immune thrombocytopenic purpura in children. Secondary follicles with well developed germinal centers, histiocytes and neutrophils in red pulp, dilated sinuses, germinal idoipatik contain platelet antigen CD41 and show phagocytosis of nuclear debris and periarterial fibrosis Usually mild myeloid metaplasia or extramedullary hematopoiesis due to megakaryocytes Variable plasma cells in marginal zone, ldiopatik foamy or ceroid laden macrophages in red pulp due to ingestion of phospholipids from platelets Steroid treatment diminishes prominence of follicles Rarely periarterial fibrosis Arch Pathol Lab Med ; First, it has to be determined that there are no blood abnormalities other than a low platelet count, and no physical signs other than bleeding.