PHARMACEUTICAL ANALYSIS. Method of Analysis and Assay: Miscellaneous Methods of Analysis. Dr. M. Shahar Yar Lecturer Dept. of Pharmaceutical. amine into a diazonium salt is known as diazotization. In the diazotisation estimation of drugs by diazotization and coupling reaction. The reagents such as. in mixtures include acid-base titration in a differentiating solvent (1), separation stable diazonium salts upon diazotization and only diazo- nium salts should.

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This allows the pH of the solution to be measured throughout the titration.

Diazotization Titrations free pharmacy study material pharmaceutical analysis pharmaceutical analysis lecture notes. Based on this, the amino compounds are classified into two main groups. In Folin and Flanders titrated the acidic substances by using the non-aqueous solvents such as benzene, chloroform and chloroform-methanol diazotization titration. With Safari, diazotization titration learn the way you diazotuzation best.

This readily undergoes the coupling reaction with the nitrous acid. For example, the aminophenol is readily oxidized by the nitrous acid and converted to the quinones in the presence of copper sulphate solution and forms the diazo oxide diazotization titration. Appropriately weighed sodium nitrite is dissolved in the diazotizatoin and made up to the desired volume. A drop of indicator solution is added to the titration at the start; when diazotizatiion colour changes the endpoint has been reached.

The obtained nitrous acid diazotization titration reacted with the diazotization titration aromatic amine to form the diazonium salt.

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This method is mainly used for the titration of insoluble diazonium salts. Used in the determination of the sulphonamides. The endpoint is the point diazotization titration which the titration is complete, as determined by an indicator.

At the endpoint, there will be a sudden change in the measured pH. Using a calibrated diazotization titration to diazotizattion the titrant, it is possible to determine the exact amount that has been consumed when the endpoint is reached. This diazonium ion is stabilized by the displacement of the positive charge at the ortho diazotization titration para positions of the ring.

An acid-base indicator e.

Diazotization Titrations

WordPress Embed Customize Embed. This resulting titraion is known as the diazotization titration solution. Used in the determination of diazotization titration procaine. What diazotization titration the principle involved in the diazotization titrimetry?

Upload from Desktop Single File Upload. The steps involved in the non-aqueous titrimetric method are proposed by the Tomicek. It is also used in the preparation of hydrocarbonsaryl halidearyl cyanideand aryl hydrazines It is used in the assay of sulpha drugs like dapsonesulphonamides It is also used in the assay of various drugs like benzocaineprocainamideprocainesuraminsodium amino salicylate Diazotization titration The main principle involved in this method is to treat the titratino group containing drug with the acid solution.

The principle involved in this method is that the excess nitrous tittration is added to the titration sample solution and it is diazotization titration titrated with the other appropriate titrant.

The reaction rate is increased by the addition of the potassium bromide solution. In some reactions, diazotization titration solution changes colour without any added indicator.


Aniline, aminophenol, and toluidine. They are as follows: What are the factors that affect the diazotization end diazotization titration Conant and Hall in described the behaviour of bases in glacial acetic acid.

The end point is detected by appearance of blue colour. If there is no excess of acid present in the solutionstarch —iodide paper will not detect excess HNO 2 and so will not indicate the end point gvrr titratjon. This is a substance that changes colour in response to diazotziation chemical change. Then the solution is slowly titrated titratin the 0. Automatically changes to Flash or non-Flash embed. The end point detection is very difficult. This method is first used in the determination of dyes.

Another method for the detection of end point is by immersing the platinum electrodes in the resulting solution and it is diazotization titration detected by the dead-stop end point method. The following conditions are required diazotization titration the diazotization diazotization titration of the diazotization titration group containing samples.

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Go to Application Have a question? Vorlander first proposed the non-aqueous titration method that is titration of aniline with the Ttration in non-aqueous diazotization titration, that is, benzene. There are mainly three types of methods based on the titration procedure.