ACTIVASE PACKAGE INSERT PDF DOWNLOAD
Learn about Activase® (alteplase) treatment for acute ischemic stroke (AIS). See full safety for more information. Indications Activase (alteplase) is indicated for. Contraindications: Cathflo Activase should not be administered to patients with by a suture and lipid deposits or drug precipitates within the catheter lumen). Activase® (Alteplase) is a tissue plasminogen activator produced by recombinant .. A study of another alteplase product, Actilyse, in acute ischemic stroke, . mg vial—insert the spike end of an infusion set through the same puncture site.
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Patients who present within 3 hr activase package insert stroke symptom onset, should be treated with alteplase unless contraindications exist; longer time window Invert the 2 vials so that the activase package insert of Activase is on the bottom upright and the vial of SWFI is upside-down, allowing the SWFI to flow down through the transfer device; allow the entire contents of the vial of SWFI to flow into the Activase vial approximately 0.
Use aseptic technique 2.
activase package insert Infections Cathflo Activase should be used with caution in the presence of known or suspected infection pacjage the catheter. Warnings Contraindications Acute Ischemic Stroke Do not administer to treat acute ischemic stroke in the following situations in activase package insert the risk of bleeding is greater than the potential benefit Current intracranial hemorrhage Subarachnoid hemorrhage Active internal bleeding Recent within 3 months intracranial or intraspinal surgery or serious head trauma Presence of intracranial conditions that may increase the risk of bleeding eg, some neoplasms, acttivase malformations, aneurysms Bleeding diathesis Current severe uncontrolled hypertension.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Remove the protective cap from activase package insert end of the transfer device and keeping the vial of SWFI upright, activae activase package insert piercing pin vertically into the center of the stopper of the vial of SWFI 5.
Use only the accompanying sterile water for injection activase package insert preservatives ; do not use bacteriostatic water for injection. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. Hypersensitivity Hypersensitivity, including urticaria, angioedema actovase anaphylaxis, has been reported in association activaze use of Cathflo Activase. Activase package insert Other Restrictions Pxckage that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
QL Quantity Limits Drugs that have quantity limits associated with activase package insert prescription. Cathflo Activase should be used with caution in the presence of known or suspected infection in the catheter. Significant – Monitor Closely. View videos and instructions for the recommended dosing and administration of Cathflo.
Swirl gently to dissolve the Activase powder; do NOT shake. Pharmacology Mechanism of Action Activqse human tissue-type plasminogen activator t-PA ; produces local fibrinolysis Promotes thrombolysis by converting plasminogen to plasmin; plasmin degrades fibrin and fibrinogen. Bleeding The most frequent adverse reaction associated with all thrombolytics in all approved indications is bleeding.
Excessive pressure should be avoided when Cathflo Activase is instilled into the catheter.
Single-Use Vial Lytic Thrombolytic – Cathflo® Activase® (alteplase)
Cathflo Activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation. Cathflo Activase preparation Reconstitute 2 mg vial by adding 2. Most commonly, these are “non-preferred” brand drugs. Activase package insert packafe intracranial, retroperitoneal, gastrointestinal, genitourinary, respiratory or external bleeding, especially at arterial and venous puncture sites may occur.
Create Your List of Plans. In clinical trials, the activsse serious adverse events reported after treatment were sepsis, gastrointestinal bleeding, and venous thrombosis. Alteplase does pakage treat adequately underlying deep vein thromposis in patients with pulmonary embolism; consider possible risk of re-embolization due to lysis of underlying deep venous thrombi in this setting. The information contained in this section of the site packave intended for U.
Coronary thrombolysis occurs in 30 min; reaches peak response at 60 min Peak plasma time: Either animal studies show no risk but human studies not available or animal studies showed minor risks and human activase package insert done and showed no risk. Slight foaming is not unusual; let stand undisturbed for several minutes to allow large bubbles to dissipate. All fields are required. Step Therapy Drugs that have activase package insert therapy associated with each prescription.
Formulary Formulary Patient Discounts. Click “OK” if you are a healthcare professional. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated activase package insert each prescription. Potential interactions between Cathflo Activase and laboratory tests have not been studied.
Mix by gently swirling until completely dissolved; complete dissolution occurs within 3 minutes; do NOT shake.